Endocrine System > Hypothalamus and Pituitary

Development and Anatomy of the Pituitary Gland

The hypophysis is an amalgam of two tissues. Early in gestation a finger of ectoderm grows upward from the roof of the mouth. This protrusion is called Rathke's pouch and will develop into the anterior pituitary or adenohypophysis.

At the same time that Rathke's pouch is developing, another finger of ectodermal tissue evaginates ventrally from the diencephalon of the developing brain. This extension of the ventral brain will become the posterior pituitary or neurohypophysis. Ultimately, the two tissues grow into one another and become tightly apposed, but their structure remains distinctly different, reflecting their differing embryological origins.

Both the adenohypophysis and neurohypophysis can be subdivided based on gross and histologic features. The terminology used is as follows:



Histology of the Adenohypophysis

Updated 2018. Send comments to Richard.Bowen@colostate.edu